Template for Reporting Results of HER2 (ERBB2) Biomarker Testing of Specimens From Patients With Adenocarcinoma of the Stomach or Esophagogastric Junction.
نویسندگان
چکیده
منابع مشابه
HER2/neu Expression in Gastric and Esophagogastric Junction Adenocarcinoma
Background: Gastric cancer is one of the most commonly diagnosed cancer and one of the most common causes of cancerrelated deaths worldwide. HER-2/neu, a well-recognized factor, is indicated in the development of certain human solid tumors, notably breast cancer. High expression of HER2/neu has correlated with poor prognosis. Studies reveal combination of treatment with antibody targeting HER-2...
متن کاملThe incidence and prognostic value of HER2 overexpression and cyclin D1 expression in patients with gastric or gastroesophageal junction adenocarcinoma in Israel
Human epidermal growth factor 2 (HER2) positivity rates for gastric or gastroesophageal junction (GEJ) adenocarcinoma have been reported at 15-25%. Cyclin D1 (BCL1) is a non-specific proliferative marker. The prognostic significance of HER2 and cyclin D1 is inconclusive, with contradictory data. The aim of this study was to evaluate the incidence of HER2 overexpression in gastric or GEJ patient...
متن کاملHER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology.
CONTEXT - ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy for patients with advanced gastroesophageal adenocarcinoma (GEA). However, there are no comprehensive guidelines for the assessment of HER2 in patients with GEA. OBJECTIVES - To establish an evidence-based guideline for HER2 testing in patients with GEA, ...
متن کاملIsolated Splenic Metastases of Her2+++ Gastroesophageal Junction Adenocarcinoma
Isolated metastases from gastric adenocarcinoma to the spleen are very infrequent. Usually, there are multiple metastases from gastric cancer, and isolated splenic metastases are very rare [Lam and Tang: Arch Pathol Lab Med 2000;124:526-530] because of certain anatomical and physiological characteristics (e.g., angulation between the splenic artery and celiac trunk, paucity of afferent lymph fl...
متن کاملHer2/neu testing in gastric cancer: evaluating the risk of sampling errors
BACKGROUND We evaluated the risk of sampling errors in specimens of biopsy size, which may be caused by heterogeneous overexpression of Her2/neu in gastric cancer (GC). PATIENTS AND METHODS The study cohort comprised 454 gastrectomy patients with adenocarcinoma of the stomach or esophago-gastric junction. Tissue micro-arrays (TMAs) served as 'biopsy procedure' and were generated from formalin...
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عنوان ژورنال:
- Archives of pathology & laboratory medicine
دوره 139 5 شماره
صفحات -
تاریخ انتشار 2015